Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation.

ABSTRACT: Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses. Although the discrete function of these enzymes has been extensively characterized, recent reports have suggested that they can also form heterodimers with functional consequences. However, lack of structural characterization of a putative ERAP1/ERAP2 dimer has limited our understanding of its biological role and significance. To address this, we employed computational molecular dynamics calculations to explore the topology of interactions between these two, based on experimentally determined homo-dimerization interfaces observed in crystal structures of

SUBMITTER: Papakyriakou A 

PROVIDER: S-EPMC9065437 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature