Toxicological Assessment of Flavor Ingredients in E-Vapor Products.

ABSTRACT: Many flavor ingredients are often used in potentially reduced-risk tobacco products (such as e-vapor products). Although most are "generally recognized as safe (GRAS)" when used in food, there is limited information available on their long-term health effects when delivered by inhalation. While obtaining route-of-exposure-specific toxicological data on flavor ingredients is critical to product evaluation, the large number of individual flavor ingredients available and their potential combinations render classical toxicological assessment approaches impractical, as they may require years of preclinical investigations and thousands of laboratory animals. Therefore, we propose a pragmatic approach in which flavor ingredients are initially assigned to groups of structurally related compounds (

SUBMITTER: Sciuscio D 

PROVIDER: S-EPMC9065440 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature