Augmentation of Extracellular ATP Synergizes With Chemotherapy in Triple Negative Breast Cancer.

ABSTRACT:

Introduction

Breast cancer affects two million patients worldwide every year and is the most common cause of cancer-related death among women. The triple-negative breast cancer (TNBC) sub-type is associated with an especially poor prognosis because currently available therapies fail to induce long-lasting responses. Therefore, there is an urgent need to develop novel therapies that result in durable responses. One universal characteristic of the tumor microenvironment is a markedly elevated concentration of extracellular adenosine triphosphate (eATP). Chemotherapy exposure results in further increases in eATP through its release into the extracellular space of cancer cells via P2RX channels. eATP is degraded by eATPases. Given that eATP is toxic to cancer cells, we hypothesi

SUBMITTER: Manouchehri JM 

PROVIDER: S-EPMC9065442 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature