A Finite Element Model of Cerebral Vascular Injury for Predicting Microbleeds Location.

ABSTRACT: Finite Element (FE) models of brain mechanics have improved our understanding of the brain response to rapid mechanical loads that produce traumatic brain injuries. However, these models have rarely incorporated vasculature, which limits their ability to predict the response of vessels to head impacts. To address this shortcoming, here we used high-resolution MRI scans to map the venous system anatomy at a submillimetre resolution. We then used this map to develop an FE model of veins and incorporated it in an anatomically detailed FE model of the brain. The model prediction of brain displacement at different locations was compared to controlled experiments on post-mortem human subject heads, yielding over 3,100 displacement curve comparisons, which showed fair to excellent correlation bet

SUBMITTER: Duckworth H 

PROVIDER: S-EPMC9065595 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature