Theoretical and experimental studies of an oseltamivir-triazole-based thermoresponsive organogel.

ABSTRACT: Low-molecular weight organic gelators have been of significant interest in recent years because of their interesting properties and potential applications in sensing technology, biomedicine and drug delivery. Herein, the synthesis, characterization and gelation properties of new oseltamivir conjugates are reported. The oseltamivir-triazole conjugate 1 was synthesized via a click-reaction in a 75% yield. The key features of this conjugate include the presence of amide, flexible ester linkages and a triazole scaffold linking a hydrophobic alkyl chain. The conjugate 1, possessing a long alkyl chain, showed gelation properties in various apolar organic solvents. This gelation behavior was not observed in the case of the deesterified conjugate 2; this indicated the necessity of the alkyl

SUBMITTER: Kumar S 

PROVIDER: S-EPMC9065751 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature