Sialyl LewisX mimic-decorated liposomes for anti-angiogenic everolimus delivery to E-selectin expressing endothelial cells.

ABSTRACT: In this study, we developed novel E-selectin-targeting liposomes, i.e., 3'-(1-carboxy)ethyl sialyl LewisX (3'-CE sLeX) mimic liposomes, for targeted delivery of everolimus (EVE) in anti-angiogenic therapy. We investigated the uptake and efficacy of these E-selectin targeting liposomes in inflammatory cytokine-treated human umbilical vein endothelial cells (HUVECs). The uptake of EVE in 3'-CE sLeX mimic liposomes increased steadily and almost caught up with the uptake of plain EVE at 3 h, which was higher than that in PEGylated liposomes (PEG-liposomes). Inhibition of uptake by anti-E-selectin antibody suggested involvement of E-selectin-mediated endocytotic processes. Migration in cells treated with EVE/3'-CE sLeX mimic liposomes was suppressed by more than half when compared to the

SUBMITTER: Chantarasrivong C 

PROVIDER: S-EPMC9065773 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature