N-terminal pro brain natriuretic peptide reference values in community-dwelling older adults.

ABSTRACT:

Aims

Available upper reference levels (URLs) in older adults for N-terminal pro brain natriuretic peptide (NT-proBNP), an established biomarker for heart failure, are mainly based on small samples. We aimed to identify NT-proBNP URL in a population-based reference sample of individuals aged ≥65 years.

Methods and results

We analysed established NT-proBNP predictors using quantile regression among 2459 participants of two-independent population-based cohorts located in Germany, the Activity and Function in the Elderly Study (ActiFE, n = 1450) and the Study of Health in Pomerania (SHIP-TREND-0, n = 1009). Based on predictors a reference population of 441 subjects (ActiFE, n = 227; SHIP-TREND-0, n = 214) without history of diabetes, cardiovascular, or pulmonary diseases and wit

SUBMITTER: Braisch U 

PROVIDER: S-EPMC9065825 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature