Mechanistic insights into chloride-related heart failure progression according to the plasma volume status.

ABSTRACT:

Aims

Two types of heart failure (HF) progression were recently proposed on the basis of an increased vs. non-increased serum chloride concentration. The applicability of this concept to real-world HF pathophysiology requires further investigation. The present study evaluated the mechanisms of HF progression to a different type according to changes in the estimated plasma volume status (ePVS).

Methods and results

Data from 47 patients (32% men; 78.2 ± 9.7 years of age) with stable to worsening HF (37.5 ± 16 days) were analysed. Physical examination, standard blood tests, and b-type natriuretic peptide (BNP) measurements were conducted. The ePVS was calculated as follows: ePVS (dL/g) = [100 - haematocrit (%)]/[haemoglobin (g/dL)]. For the study subjects as a whole (n = 47), ch

SUBMITTER: Kataoka H 

PROVIDER: S-EPMC9065841 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature