Cardiovascular outcomes associated with treatment of type 2 diabetes in patients with ischaemic heart failure.

ABSTRACT:

Aim

The optimal strategy for diabetes control in patients with heart failure (HF) following myocardial infarction (MI) remains unknown. Metformin, a guideline-recommended therapy for patients with chronic HF and type 2 diabetes mellitus (T2DM), is associated with reduced mortality and HF hospitalizations. However, worse outcomes have been reported when used at the time of MI. We compared outcomes of patients with T2DM and HF of ischaemic aetiology according to antidiabetic treatment.

Methods and results

This study used linked data from primary care, hospital admissions, and death registries for 4.7 million inhabitants in England, as part of the CALIBER resource. The primary endpoint was a composite of cardiovascular mortality and HF hospitalization. The secondary endpoints w

SUBMITTER: Godec TR 

PROVIDER: S-EPMC9065866 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature