Sodium-glucose cotransporter-2 inhibitors in heart failure: an updated meta-analysis.

ABSTRACT:

Aims

We aimed to examine efficacy and safety outcomes of sodium-glucose cotransporter-2 inhibitor (SGLT2i) for the treatment of heart failure (HF), especially in patients with heart failure with preserved ejection fraction (HFpEF).

Methods and results

PubMed, Web of Science, and Cochrane Library were searched to identify randomized controlled trials comparing SGLT2i vs. placebo in HF patients. A total of 10 studies with 23 852 HF patients were eventually included. Compared with placebo, SGLT2i is associated with a lower incidence of composite of first hospitalization for heart failure (HHF) or cardiovascular death (CV death) [hazard ratio (HR) = 0.76 95% confidence interval (CI) = 0.71-0.81], which is consistent regardless of the diabetes status, type of gliflozines used, an

SUBMITTER: Cao Y 

PROVIDER: S-EPMC9065870 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature