Maternal undernutrition alters the skeletal muscle development and methylation of myogenic factors in goat offspring.

ABSTRACT:

Objective

The effects of maternal undernutrition during midgestation on muscle fiber histology, myosin heavy chain (MyHC) expression, methylation modification of myogenic factors, and the mammalian target of rapamycin (mTOR) signaling pathway in the skeletal muscles of prenatal and postnatal goats were examined.

Methods

Twenty-four pregnant goats were assigned to a control (100% of the nutrients requirement, n = 12) or a restricted group (60% of the nutrients requirement, n = 12) between 45 and 100 days of gestation. Descendants were harvested at day 100 of gestation and at day 90 after birth to collect the femoris muscle tissue.

Results

Maternal undernutrition increased (p<0.05) the fiber area of the vastus muscle in the fetuses and enhanced (p<0.01) the proportions

SUBMITTER: Zhou X 

PROVIDER: S-EPMC9066034 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature