Helminthic dehydrogenase drives PGE₂ and IL-10 production in monocytes to potentiate Treg induction.

ABSTRACT: Immunoregulation of inflammatory, infection-triggered processes in the brain constitutes a central mechanism to control devastating disease manifestations such as epilepsy. Observational studies implicate the viability of Taenia solium cysts as key factor determining severity of neurocysticercosis (NCC), the most common cause of epilepsy, especially in children, in Sub-Saharan Africa. Viable, in contrast to decaying, cysts mostly remain clinically silent by yet unknown mechanisms, potentially involving Tregs in controlling inflammation. Here, we show that glutamate dehydrogenase from viable cysts instructs tolerogenic monocytes to release IL-10 and the lipid mediator PGE₂ . These act in concert, converting naive CD4⁺ T cells into CD127^- CD25^hi Fo

SUBMITTER: Prodjinotho UF 

PROVIDER: S-EPMC9066053 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature