LincRNA-EPS impairs host antiviral immunity by antagonizing viral RNA-PKR interaction.

ABSTRACT: LincRNA-EPS is an important regulator in inflammation. However, the role of lincRNA-EPS in the host response against viral infection is unexplored. Here, we show that lincRNA-EPS is downregulated in macrophages infected with different viruses including VSV, SeV, and HSV-1. Overexpression of lincRNA-EPS facilitates viral infection, while deficiency of lincRNA-EPS protects the host against viral infection in vitro and in vivo. LincRNA-EPS^-/- macrophages show elevated expression of antiviral interferon-stimulated genes (ISGs) such as Mx1, Oas2, and Ifit2 at both basal and inducible levels. However, IFN-β, the key upstream inducer of these ISGs, is downregulated in lincRNA-EPS^-/- macrophages compared with control cells. RNA pulldown and mass spectrometry results indicate

SUBMITTER: Zhu J 

PROVIDER: S-EPMC9066075 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature