A cobalt-doped iron oxide nanozyme as a highly active peroxidase for renal tumor catalytic therapy.

ABSTRACT: The Fe₃O₄ nanozyme, the first reported nanozyme with intrinsic peroxidase-like activity, has been successfully employed for various diagnostic applications. However, only a few studies have been reported on the therapeutic applications of the Fe₃O₄ nanozyme partly due to its low affinity to the substrate H₂O₂. Herein, we report a new strategy for improving the peroxidase-like activity and affinity of the Fe₃O₄ nanozyme to H₂O₂ to generate reactive oxygen species (ROS) for kidney tumor catalytic therapy. We showed that cobalt-doped Fe₃O₄ (Co@Fe₃O₄) nanozymes possessed stronger peroxidase activity and a 100-fold higher affinity to H_2</

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9066162 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature