Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors.
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ABSTRACT:
SUBMITTER: Esposito A
PROVIDER: S-EPMC9066171 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
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Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors.
Esposito Anna A De Gregorio Eliana E De Fenza Maria M D'Alonzo Daniele D Satawani Anil A Guaragna Annalisa A
RSC advances 20190710 37
The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens <i>Acinetobacter baumannii</i> and <i>Staphylococcus aureus</i> is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-negative and -positive bacteria. ...[more]
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