Exomer complex regulates protein traffic at the TGN through differential interactions with cargos and clathrin adaptor complexes.

ABSTRACT: Protein sorting at the trans-Golgi network (TGN) usually requires the assistance of cargo adaptors. However, it remains to be examined how the same complex can mediate both the export and retention of different proteins or how sorting complexes interact among themselves. In Saccharomyces cerevisiae, the exomer complex is involved in the polarized transport of some proteins from the TGN to the plasma membrane (PM). Intriguingly, exomer and its cargos also show a sort of functional relationship with TGN clathrin adaptors that is still unsolved. Here, using a wide range of techniques, including time-lapse and BIFC microscopy, we describe new molecular implications of the exomer complex in protein sorting and address its different layers of functional interaction with clathrin adaptor complexe

SUBMITTER: Anton-Plagaro C 

PROVIDER: S-EPMC9066374 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature