Improved production of ⁷⁶Br, ⁷⁷Br and ^80mBr via CoSe cyclotron targets and vertical dry distillation.

ABSTRACT:

Introduction

The radioisotopes of bromine are uniquely suitable radiolabels for small molecule theranostic radiopharmaceuticals but are of limited availability due to production challenges. Significantly improved methods were developed for the production and radiochemical isolation of clinical quality ⁷⁶Br, ⁷⁷Br, and ^80mBr. The radiochemical quality of the radiobromine produced using these methods was tested through the synthesis of a novel ⁷⁷Br-labeled inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1), a DNA damage response protein.

Methods

⁷⁶Br, ⁷⁷Br, and ^80mBr were produced in high radionuclidic purity via the proton irradiation of novel isotopically-enriched Co⁷⁶Se, Co⁷⁷

SUBMITTER: Ellison PA 

PROVIDER: S-EPMC9066421 | biostudies-literature | 2020 Jan - Feb

REPOSITORIES: biostudies-literature