Monooxygenase-catalyzed regioselective hydroxylation for the synthesis of hydroxyequols.

ABSTRACT: Monooxygenases exhibiting high activity and differing regioselectivity for the dietary isoflavone metabolite equol were discovered among enzymes in the HpaBC family by a genome mining approach. These enzymes enabled the one-step product-selective synthesis of 3'- and 6-hydroxyequols from equol and molecular oxygen.

SUBMITTER: Hashimoto T 

PROVIDER: S-EPMC9066559 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature