The role of thyroglobulin doubling time in differentiated thyroid cancer: a meta-analysis.

ABSTRACT:

Objective

In patients with differentiated thyroid cancer (DTC), recurrences may occur in up to 20% and may have a fatal outcome in 10% of cases. Thyroglobulin doubling time (Tg-DT) values may contribute to predict response to treatment and disease recurrence in DTC patients. This study aimed to address the following questions: (1) Are Tg-DT values indicative of response to treatments in patients with DTC (i.e. 'treatment monitoring')?; (2) Is Tg-DT predictive of 2-[18F]fluoro-2-deoxy-d-glucose (2-[18F]FDG) PET/CT in patients with DTC?; (3) Are Tg-DT values predictive of DTC prognosis (i.e. 'prediction')?

Design

Systematic review and meta-analysis.

Methods

Methodology was registered in the PROSPERO database (CRD42021257947). A systematic search was carried out in PubMe

SUBMITTER: Giovanella L 

PROVIDER: S-EPMC9066573 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature