Site-Selective Catalytic Epoxidation of Alkene with Tunable, Atomic Precision by Molecularly Imprinted Artificial Epoxidases.

ABSTRACT: Distinction of chemical functionality by their local chemical environment is a skill mastered by enzymes, evident from the selective synthesis, cleavage, and transformation of peptides, nucleic acids, and polysaccharides that abound with the same type of functional groups. In contrast, synthetic catalysts are generally better at differentiating functional groups based on their electronic and steric properties. Here we report artificial epoxidases prepared through molecular imprinting of surface-core doubly cross-linked micelles, followed by efficient functionalization of the imprinted site in the micellar core via photoaffinity labeling. The size and shape of the active sites are tuned by the modularly synthesized templates, with the oxygen-delivering peroxy acid group positioned accuratel

SUBMITTER: Bose I 

PROVIDER: S-EPMC9066603 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature