Population pharmacokinetic model and limited sampling strategy for clozapine using plasma and dried blood spot samples.

ABSTRACT:

Background

To improve efficacy, therapeutic drug monitoring is often used in clozapine therapy. Trough level monitoring is regular, but trough levels provide limited information about the pharmacokinetics of clozapine and exposure in time. The area under the concentration time curve (AUC) is generally valued as better marker of drug exposure in time but calculating AUC needs multiple sampling. An alternative approach is a limited sampling scheme in combination with a population pharmacokinetic model meant for Bayesian forecasting. Furthermore, multiple venepunctions can be a burden for the patient, whereas collecting samples by means of dried blood spot (DBS) sampling can facilitate AUC-monitoring, making it more patient friendly.

Objective

Development of a population pharma

SUBMITTER: Geers LM 

PROVIDER: S-EPMC9066631 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature