Phosphonic acid mediated practical dehalogenation and benzylation with benzyl halides.

ABSTRACT: For the first time, by using H₃PO₃/I₂ system, various benzyl chlorides, bromides and iodides were dehalogenated successfully. In the presence of H₃PO₃, benzyl halides underwent electrophilic substitution reactions with electron-rich arenes, leading to a broad range of diarylmethanes in good yields. These transformations feature green, cheap reducing reagents and metal-free conditions. A possible mechanism was proposed.

SUBMITTER: Xiao J 

PROVIDER: S-EPMC9066657 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature