Glutamate levels across deep brain structures in patients with a psychotic disorder and its relation to cognitive functioning.

ABSTRACT:

Background

Patients with psychotic disorders often show prominent cognitive impairment. Glutamate seems to play a prominent role, but its role in deep gray matter (DGM) regions is unclear.

Aims

To evaluate glutamate levels within deep gray matter structures in patients with a psychotic disorder in relation to cognitive functioning, using advanced spectroscopic acquisition, reconstruction, and post-processing techniques.

Methods

A 7-Tesla magnetic resonance imaging scanner combined with a lipid suppression coil and subject-specific water suppression pulses was used to acquire high-resolution magnetic resonance spectroscopic imaging data. Tissue fraction correction and registration to a standard brain were performed for group comparison in specifically delineated DGM re

SUBMITTER: Broeders TA 

PROVIDER: S-EPMC9066676 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature