JNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function.

ABSTRACT:

Background and aim

The appearance of alterations in normal metabolic activity has been increasingly considered a risk factor for the development of sporadic and late-onset neurodegenerative diseases. In this report, we induced chronic metabolic stress by feeding of a high-fat diet (HFD) in order to study its consequences in cognition. We also studied the effects of a loss of function of isoforms 1 and 3 of the c-Jun N-terminal Kinases (JNK), stress and cell death response elements.

Methods

Animals were fed either with conventional chow or with HFD, from their weaning until their sacrifice at 9 months. Before sacrifice, body weight, intraperitoneal glucose and insulin tolerance test (IP-GTT and IP‑ITT) were performed to evaluate peripheral biometrics. Additionally, cognitive

SUBMITTER: Busquets O 

PROVIDER: S-EPMC9066854 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature