Effect of traffic-related air pollution on cough in adults with polymorphisms in several cough-related genes.

ABSTRACT: With prevalent global air pollution, individuals with certain genetic predispositions and sensitivities are at of higher risk of developing respiratory symptoms including chronic cough. Studies to date have relied on patient-filled questionnaires in epidemiological studies to evaluate the gene-by-environment interactions. In a controlled human exposure study, we evaluated whether genetic risk score (GRS) based on cough-related single-nucleotide polymorphisms (SNPs) are associated with a cough count over 24 h post-exposure to diesel exhaust (DE), a model for traffic-related air pollution. DE is a mixture of several known air pollutants including PM_2.5, CO, NO, NO₂, and volatile organic compounds. Under closely observed circumstances, we determined that GRS constructed

SUBMITTER: Yoon M 

PROVIDER: S-EPMC9066887 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature