Biological networks in gestational diabetes mellitus: insights into the mechanism of crosstalk between long non-coding RNA and N⁶-methyladenine modification.

ABSTRACT:

Background

Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy. The mechanism underlying the crosstalk between long non-coding RNAs (lncRNAs) and N⁶-methyladenine (m6A) modification in GDM remain unclear.

Methods

We generated a lncRNA-mediated competitive endogenous RNA (ceRNA) network using comprehensive data from the Gene Expression Omnibus database, published data, and our preliminary findings. m6A-related lncRNAs were identified based on Pearson correlation coefficient (PCC) analysis using our previous profiles. An integrated pipeline was established to constructed a m6A-related subnetwork thereby predicting the potential effects of the m6A-related lncRNAs.

Results

The ceRNA network was composed of 16 lncRNAs, 17 mic

SUBMITTER: Du R 

PROVIDER: S-EPMC9066898 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature