Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia.

ABSTRACT:

Background

Thrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor prognosis. The disease mechanisms of PE on a platelet level are poorly understood and only few platelet-based markers have been investigated. In sepsis, platelet mitochondrial membrane depolarization, a sensitive and early indicator of mitochondrial dysfunction and platelet cell death, correlates with disease severity and outcome as shown in previous studies. The aim of this study was to investigate platelet mitochondrial membrane potential (Mmp-Index) by flow-cytometry in patients with preeclampsia compared to controls and to assess its value in correlation with disease severity of PE and during follow-up after delivery.

Methods</

SUBMITTER: Kraemer BF 

PROVIDER: S-EPMC9066965 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature