Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis.

ABSTRACT:

Background

Unbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been suggested as a potential underlying mechanism linking environmental exposures such as micronutrient status during pregnancy with offspring health. We performed a meta-analysis on the association of maternal early-pregnancy serum ferritin concentrations, as a marker of body iron stores, and cord blood DNA methylation. We included 1286 mother-newborn pairs from two population-based prospective cohorts. Serum ferritin concentrations were measured in early pregnancy. DNA methylation was measured with the Infinium HumanMethylation450 BeadChip (Illumina). We examined epigenome-wide associations of maternal early-pregnancy serum

SUBMITTER: Taeubert MJ 

PROVIDER: S-EPMC9066980 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature