Small nucleolar RNA SNORA71A promotes epithelial-mesenchymal transition by maintaining ROCK2 mRNA stability in breast cancer.

ABSTRACT: Metastasis is the primary reason of death in patients with cancer. Small nucleolar noncoding RNAs (snoRNAs) are conserved 60-300 nucleotide noncoding RNAs, involved in post-transcriptional regulation of mRNAs and noncoding RNAs. Despite their essential roles in cancer, the roles of snoRNAs in epithelial-mesenchymal transition (EMT)-induced metastasis have not been studied extensively. Here, we used small RNA sequencing to screen for snoRNAs related to EMT and breast cancer metastasis. We found a higher expression of SNORA71A in metastatic breast cancer tissues compared to nonmetastatic samples. Additionally, SNORA71A promoted the proliferation, migration, invasion and EMT of MCF-7 and MDA-MB-231 cells. Mechanistically, SNORA71A elevated mRNA and protein levels of ROCK2, a negative regulato

SUBMITTER: Hu T 

PROVIDER: S-EPMC9067147 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature