Lesion-symptom mapping with NIHSS sub-scores in ischemic stroke patients.

ABSTRACT:

Background

Lesion-symptom mapping (LSM) is a statistical technique to investigate the population-specific relationship between structural integrity and post-stroke clinical outcome. In clinical practice, patients are commonly evaluated using the National Institutes of Health Stroke Scale (NIHSS), an 11-domain clinical score to quantitate neurological deficits due to stroke. So far, LSM studies have mostly used the total NIHSS score for analysis, which might not uncover subtle structure-function relationships associated with the specific sub-domains of the NIHSS evaluation. Thus, the aim of this work was to investigate the feasibility to perform LSM analyses with sub-score information to reveal category-specific structure-function relationships that a total score may not reveal.

SUBMITTER: Rajashekar D 

PROVIDER: S-EPMC9067270 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature