Total synthesis of the plant alkaloid racemic microthecaline A: first example of a natural product bearing a tricyclic quinoline-serrulatane scaffold.

ABSTRACT: The first total synthesis of racemic microthecaline A, a quinoline serrulatane alkaloid, isolated from the Australian desert plant Eremophila microtheca is described. The natural product was synthesized in ten steps, starting from ethyl 4-bromo-6-methoxy-8-methylquinoline-3-carboxylate in 8% overall yield.

SUBMITTER: Penjarla TR 

PROVIDER: S-EPMC9067311 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature