Synthesis and antibacterial and antiviral activities of myricetin derivatives containing a 1,2,4-triazole Schiff base.

ABSTRACT: A series of novel myricetin derivatives containing a 1,2,4-triazole Schiff base were designed and synthesized. Their structures were systematically characterized using ¹H NMR, ¹³C NMR, and HRMS. During antibacterial bioassays, 6f, 6i, and 6q demonstrated a good inhibitory effect against Xanthomonas axonopodis pv. citri (Xac), with half-maximal effective concentration (EC₅₀) values of 10.0, 9.4, and 8.8 μg mL^-1, respectively, which were better than those of bismerthiazol (54.9 μg mL^-1) and thiodiazole copper (61.1 μg mL^-1). Note that 6w demonstrated a good inhibitory effect against Ralstonia solanacearum (Rs) with and EC₅₀ value of 15.5 μg mL^-1, which was better than th

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9067368 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature