CHD4 is recruited by GATA4 and NKX2-5 to repress noncardiac gene programs in the developing heart.

ABSTRACT: The nucleosome remodeling and deacetylase (NuRD) complex is one of the central chromatin remodeling complexes that mediates gene repression. NuRD is essential for numerous developmental events, including heart development. Clinical and genetic studies have provided direct evidence for the role of chromodomain helicase DNA-binding protein 4 (CHD4), the catalytic component of NuRD, in congenital heart disease (CHD), including atrial and ventricular septal defects. Furthermore, it has been demonstrated that CHD4 is essential for mammalian cardiomyocyte formation and function. A key unresolved question is how CHD4/NuRD is localized to specific cardiac target genes, as neither CHD4 nor NuRD can directly bind DNA. Here, we coupled a bioinformatics-based approach with mass spectrometry analyses t

SUBMITTER: Robbe ZL 

PROVIDER: S-EPMC9067406 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature