Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer.

ABSTRACT:

Background

Identification of residual disease in patients with localized non-small cell lung cancer (NSCLC) following treatment with curative intent holds promise to identify patients at risk of relapse. New methods can detect circulating tumour DNA (ctDNA) in plasma to fractional concentrations as low as a few parts per million, and clinical evidence is required to inform their use.

Patients and methods

We analyzed 363 serial plasma samples from 88 patients with early-stage NSCLC (48.9%/28.4%/22.7% at stage I/II/III), predominantly adenocarcinomas (62.5%), treated with curative intent by surgery (n = 61), surgery and adjuvant chemotherapy/radiotherapy (n = 8), or chemoradiotherapy (n = 19). Tumour exome sequencing identified somatic mutations and plasma was analyzed using p

SUBMITTER: Gale D 

PROVIDER: S-EPMC9067454 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature