Differential translation elongation directs protein synthesis in response to acute glucose deprivation in yeast.

ABSTRACT: Protein synthesis is energetically expensive and its rate is influenced by factors such as cell type and environment. Suppression of translation is a canonical response to stressful changes in the cellular environment. In particular, inhibition of the initiation step of translation has been highlighted as the key control step in stress-induced translational suppression as mechanisms that quickly suppress initiation are well-conserved. However, cells have evolved complex regulatory means to control translation apart from initiation. Here, we examine the role of the elongation step of translation in yeast subjected to acute glucose deprivation. The use of ribosome profiling and in vivo reporter assays demonstrated elongation rates slow progressively following glucose removal. We obser

SUBMITTER: Guzikowski AR 

PROVIDER: S-EPMC9067459 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature