Role of mononuclear stem cells and decellularized amniotic membrane in the treatment of skin wounds in rats.

ABSTRACT: Stem cells (SC) and amniotic membrane (AM) are recognized for their beneficial impacts on the healing of cutaneous wounds. Thus, this study evaluated the capacity of tissue repair in a skin lesion rat model. Forty Wistar rats were randomized into four groups: group I - control, with full-thickness lesions on the back, without SC or AM; group II-injected SC; group III - covered by AM; group IV-injected SC and covered by AM. Lesion closure was assessed using contraction rate (Cr). Histochemical and immunohistochemical analyses were performed, and collagen, elastic fibers, fibroblast differentiation factor (TGF-β), collagen remodeling (MMP-8), and the number of myofibroblasts and blood vessels (α-SMA) were evaluated. On the 7^th postoperative day, Cr 1^st-7^th da

SUBMITTER: Takejima AL 

PROVIDER: S-EPMC9067462 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature