Local detection of pH-induced disaggregation of biocompatible micelles by fluorescence switch ON.

ABSTRACT: Fluorogenic nanoparticles (NPs) able to sense different physiological environments and respond with disaggregation and fluorescence switching OFF/ON are powerful tools in nanomedicine as they can combine diagnostics with therapeutic action. pH-responsive NPs are particularly interesting as they can differentiate cancer tissues from healthy ones, they can drive selective intracellular drug release and they can act as pH biosensors. Controlled polymerization techniques are the basis of such materials as they provide solid routes towards the synthesis of pH-responsive block copolymers that are able to assemble/disassemble following protonation/deprotonation. Ring opening metathesis polymerization (ROMP), in particular, has been recently exploited for the development of experimental nanomedici

SUBMITTER: Battistelli G 

PROVIDER: S-EPMC9067588 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature