Associations between microbial communities and key chemical constituents in U.S. domestic moist snuff.

ABSTRACT:

Background

Smokeless tobacco (ST) products are widely used throughout the world and contribute to morbidity and mortality in users through an increased risk of cancers and oral diseases. Bacterial populations in ST contribute to taste, but their presence can also create carcinogenic, Tobacco-Specific N-nitrosamines (TSNAs). Previous studies of microbial communities in tobacco products lacked chemistry data (e.g. nicotine, TSNAs) to characterize the products and identify associations between carcinogen levels and taxonomic groups. This study uses statistical analysis to identify potential associations between microbial and chemical constituents in moist snuff products.

Methods

We quantitatively analyzed 38 smokeless tobacco products for TSNAs using liquid chromatography with

SUBMITTER: Tyx RE 

PROVIDER: S-EPMC9067656 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature