An orthologous gene coevolution network provides insight into eukaryotic cellular and genomic structure and function.

ABSTRACT: The evolutionary rates of functionally related genes often covary. We present a gene coevolution network inferred from examining nearly 3 million orthologous gene pairs from 332 budding yeast species spanning ~400 million years of evolution. Network modules provide insight into cellular and genomic structure and function. Examination of the phenotypic impact of network perturbation using deletion mutant data from the baker's yeast Saccharomyces cerevisiae, which were obtained from previously published studies, suggests that fitness in diverse environments is affected by orthologous gene neighborhood and connectivity. Mapping the network onto the chromosomes of S. cerevisiae and Candida albicans revealed that coevolving orthologous genes are not physically clustered in

SUBMITTER: Steenwyk JL 

PROVIDER: S-EPMC9067921 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature