Hydrogen sulfide protects retina from blue light-induced photodamage and degeneration via inhibiting ROS-mediated ER stress-CHOP apoptosis signal.

ABSTRACT: Background: Hydrogen sulfide (H₂S) is a small reducing gas molecule with various biological functions such as anti-oxidative, anti-apoptotic and anti-inflammatory activities. In this study, we investigated the therapeutic effects of exogenous H₂S in the experimental models of retinal photodamage in vivo and in vitro.Methods: Rats with open eyelids were pretreated with H₂S (80~120 μmol/kg) for 10 days and then continuously exposed to blue light (435~445nm, 11.2W/m2) for 8 h to establish in vivo experimental model. ARPE-19 cells were pretreated with H₂S and then exposed to blue light to establish in vitro experimental model.Results: In vivo experiments, H₂S significantly ameliorated blue light-induced retinal oxidati

SUBMITTER: Zhu S 

PROVIDER: S-EPMC9067965 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature