Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors.

ABSTRACT: Dendritic spines are the central postsynaptic machinery that determines synaptic function. The F-actin within dendritic spines regulates their dynamic formation and elimination. Rai14 is an F-actin-regulating protein with a membrane-shaping function. Here, we identified the roles of Rai14 for the regulation of dendritic spine dynamics associated with stress-induced depressive-like behaviors. Rai14-deficient neurons exhibit reduced dendritic spine density in the Rai14^+/- mouse brain, resulting in impaired functional synaptic activity. Rai14 was protected from degradation by complex formation with Tara, and accumulated in the dendritic spine neck, thereby enhancing spine maintenance. Concurrently, Rai14 deficiency in mice altered gene expression profile relevant to depressi

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC9068211 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature