P. aeruginosa type III and type VI secretion systems modulate early response gene expression in type II pneumocytes in vitro.

ABSTRACT:

Background

Lung airway epithelial cells are part of innate immunity and the frontline of defense against bacterial infections. During infection, airway epithelial cells secrete proinflammatory mediators that participate in the recruitment of immune cells. Virulence factors expressed by bacterial pathogens can alter epithelial cell gene expression and modulate this response. Pseudomonas aeruginosa, a Gram-negative opportunistic pathogen, expresses numerous virulence factors to facilitate establishment of infection and evade the host immune response. This study focused on identifying the role of two major P. aeruginosa virulence factors, type III (T3SS) and type VI (T6SS) secretion systems, on the early transcriptome response of airway epithelial cells in vitro.

Results

We per

SUBMITTER: Sen-Kilic E 

PROVIDER: S-EPMC9068226 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature