Cumulative burden of clinically significant aortic stenosis in community-dwelling older adults.

ABSTRACT:

Objectives

Current estimates of aortic stenosis (AS) frequency have mostly relied on cross-sectional echocardiographic or longitudinal administrative data, making understanding of AS burden incomplete. We performed case adjudications to evaluate the frequency of AS and assess differences by age, sex and race in an older cohort with long-term follow-up.

Methods

We developed case-capture methods using study echocardiograms, procedure and diagnosis codes, heart failure events and deaths for targeted review of medical records in the Cardiovascular Health Study to identify moderate or severe AS and related procedures or hospitalisations. The primary outcome was clinically significant AS (severe AS or procedure). Assessment of incident AS burden was based on subdistribution surviv

SUBMITTER: Owens DS 

PROVIDER: S-EPMC9068234 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature