COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey.
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ABSTRACT:
SUBMITTER: Lamure S
PROVIDER: S-EPMC9068260 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
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COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey.
Lamure Sylvain S Salmanton-García Jon J Robin-Marieton Elena E Jaksic Ozren O Kohn Milena M Marchesi Francesco F Marchetti Monia M El-Ashwah Shaimaa S Demirkan Fatih F Valković Toni T Fernández Noemí N Tisi Maria Chiara MC Stojanoski Zlate Z Seval Guldane Cengiz GC Ilhan Osman O Prezioso Lucia L Merelli Maria M López-García Alberto A Ledoux Marie-Pierre MP Kulasekararaj Austin A González-López Tomás-José TJ Gomes da Silva Maria M Emarah Ziad Z Duarte Rafael F RF Cattaneo Chiara C Blennow Ola O Bilgin Yavuz M YM Bergantim Rui R Batinić Josip J Cordoba Raul R Essame Jenna J Nordlander Anna A Nunes Rodrigues Raquel R Sacchi Maria Vittoria MV Zompi Sofia S Busca Alessandro A Corradini Paolo P Hoenigl Martin M Klimko Nikolai N Koehler Philipp P Pagliuca Antonio A Passamonti Francesco F Duléry Rémy R Cornely Oliver A OA Besson Caroline C Pagano Livio L
Blood advances 20220701 13
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Project description: Not available
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Project description:BackgroundPatients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality.MethodsThe survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020.ResultsThe study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March-May 2020) and the second wave (October-December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases.ConclusionsThis survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.
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