Acquired haemophilia A: Italian Consensus Recommendations on diagnosis, general management and treatment of bleeding.

ABSTRACT:

Background

Acquired haemophilia A (AHA) is a rare bleeding disorder due to autoantibodies to coagulation factor VIII that may be secondary to autoimmune diseases, cancer, drugs, pregnancy, infections, or be idiopathic. Recurrent bleeding, often severe, mostly in muscles and soft tissues, and isolated prolonged activated partial thromboplastin time (aPTT), in the absence of personal and family history of bleeding, are typical features that should raise the suspicion of AHA. Poor awareness of the disease results in diagnostic delays and inappropriate treatment.

Materials and methods

The Italian Association of Haemophilia Centres (AICE) developed consensus recommendations in cooperation with the Italian Society on Thrombosis and Haemostasis (SISET). The document was shared with

SUBMITTER: Coppola A 

PROVIDER: S-EPMC9068356 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature