Intron-mediated induction of phenotypic heterogeneity.

ABSTRACT: Intragenic regions that are removed during maturation of the RNA transcript-introns-are universally present in the nuclear genomes of eukaryotes¹. The budding yeast, an otherwise intron-poor species, preserves two sets of ribosomal protein genes that differ primarily in their introns^2,3. Although studies have shed light on the role of ribosomal protein introns under stress and starvation^4-6, understanding the contribution of introns to ribosome regulation remains challenging. Here, by combining isogrowth profiling⁷ with single-cell protein measurements⁸, we show that introns can mediate inducible phenotypic heterogeneity that confers a clear fitness advantage. Osmotic stress leads to bimodal expression of the small ribosomal subunit pr

SUBMITTER: Lukacisin M 

PROVIDER: S-EPMC9068511 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature