Circulating tumor cell enumeration for improved screening and disease detection of patients with colorectal cancer.

ABSTRACT:

Background

The immunochemical fecal occult blood test (iFOBT) for colorectal cancer (CRC) screening and the serum carcinoembryonic antigen (CEA) assay for disease detection of CRC is associated with a high false-positive rate and a low detection sensitivity, respectively. There is an unmet need to define additional modalities to complement these assays. Different subsets of circulating tumor cells (CTCs) are present in the peripheral blood of cancer patients. Whether or not CTCs testing supplements these clinical assays and is valuable for patients with CRC was investigated.

Methods

CTCs were enriched from pre-operative patients with CRC (n = 109) and the non-cancerous controls (n = 65). CTCs expressing either epithelial cell adhesion molecule (EpCAM) or podoplanin (PDPN, th

SUBMITTER: Tsai WS 

PROVIDER: S-EPMC9068522 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature