The effects of probiotics plus dietary fiber on antipsychotic-induced weight gain: a randomized clinical trial.

ABSTRACT: Probiotics plus dietary fiber has demonstrated efficacy in improving metabolic abnormalities. However, the efficacy of probiotics and dietary fiber as well as their association with microbiota in attenuating antipsychotic-induced weight gain and metabolic disturbance remains poorly understood. Here we analyzed results from the double-blind, randomized, placebo-controlled study to compare and evaluate the effects of probiotics, dietary fiber, and their combination for antipsychotic-induced weight gain in patients with a severe mental disorder. We found that probiotics plus dietary fiber was significantly superior to probiotics alone, dietary fiber only, and the placebo for weight, BMI, and total cholesterol reduction; insulin resistance was worse in the placebo group, with significant incre

SUBMITTER: Huang J 

PROVIDER: S-EPMC9068806 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature