Analysis of evolutionary and genetic patterns in structural genes of primate lentiviruses.

ABSTRACT: Primate lentiviruses (HIV1, HIV2, and Simian immunodeficiency virus [SIV]) cause immune deficiency, encephalitis, and infectious anemia in mammals such as cattle, cat, goat, sheep, horse, and puma. This study was designed and conducted with the main purpose of confirming the overall codon usage pattern of primate lentiviruses and exploring the evolutionary and genetic characteristics commonly or specifically expressed in HIV1, HIV2, and SIV. The gag, pol, and env gene sequences of HIV1, HIV2, and SIV were analyzed to determine their evolutionary relationships, nucleotide compositions, codon usage patterns, neutrality, selection pressure (influence of mutational pressure and natural selection), and viral adaptation to human codon usage. A strong 'A' bias was confirmed in all three structura

SUBMITTER: Cho M 

PROVIDER: S-EPMC9068864 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature