Naringin Relieves Diabetic Cardiac Autonomic Neuropathy Mediated by P2Y₁₄ Receptor in Superior Cervical Ganglion.

ABSTRACT: Diabetes mellitus (DM), an emerging chronic epidemic, contributes to mortality and morbidity around the world. Diabetic cardiac autonomic neuropathy (DCAN) is one of the most common complications associated with DM. Previous studies have shown that satellite glial cells (SGCs) in the superior cervical ganglia (SCG) play an indispensable role in DCAN progression. In addition, it has been shown that purinergic neurotransmitters, as well as metabotropic GPCRs, are involved in the pathophysiological process of DCAN. Furthermore, one traditional Chinese medicine, naringin may potently alleviate the effects of DCAN. Ferroptosis may be involved in DCAN progression. However, the role of naringin in DCAN as well as its detailed mechanism requires further investigation. In this research, we attempte

SUBMITTER: Tang G 

PROVIDER: S-EPMC9068893 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature